Ephb1^tm1Cmn
Targeted Allele Detail

Summary

• Symbol: Ephb1^tm1Cmn
• Name: Eph receptor B1; targeted mutation 1, Carol A Mason
• MGI ID: MGI:2677305
• Synonyms: EphB1-, EphB1^KO
• Gene: Ephb1 Location: Chr9:101799327-102231892 bp, - strand Genetic Position: Chr9, 54.15 cM
• Alliance: Ephb1^tm1Cmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85573
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 has been replaced by a neomycin resistance gene which causes a frame shift in addition to the exon loss. Western blot analysis confirmed the absence of protein product. (J:85573)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ephb1 Mutation: 43 strains or lines available

References

• Original: J:85573 Williams SE, et al., Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron. 2003 Sep 11;39(6):919-35
• All: 39 reference(s)