Sirt1^tm2Fwa
Targeted Allele Detail

Summary

• Symbol: Sirt1^tm2Fwa
• Name: sirtuin 1; targeted mutation 2, Frederick W Alt
• MGI ID: MGI:2677357
• Synonyms: SIRT1^deltaneo
• Gene: Sirt1 Location: Chr10:63154784-63174814 bp, - strand Genetic Position: Chr10, 32.57 cM
• Alliance: Sirt1^tm2Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85542
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Exons 5, 6, and 7 were replaced with a floxed neo cassette inserted by homologous recombination. (J:85542)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt1 Mutation: 81 strains or lines available

References

• Original: J:85542 Cheng HL, et al., Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9
• All: 2 reference(s)