Zap70^tm1Dlo
Targeted Allele Detail

Summary

• Symbol: Zap70^tm1Dlo
• Name: zeta-chain (TCR) associated protein kinase; targeted mutation 1, Dennis Y Loh
• MGI ID: MGI:2677447
• Synonyms: ZAP-70 -
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^tm1Dlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27768
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the entire coding region of the gene. Western blot analysis demonstrated that no detectable protein product was produced from this allele. (J:27768)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

References

• Original: J:27768 Negishi I, et al., Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature. 1995 Aug 3;376(6539):435-8
• All: 25 reference(s)