Pecam1^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Pecam1^tm1Mak
• Name: platelet/endothelial cell adhesion molecule 1; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2677448
• Synonyms: CD31-, CD31KO, PECAM-1-, PECAM-1-KO, PECAM-KO
• Gene: Pecam1 Location: Chr11:106545039-106606107 bp, - strand Genetic Position: Chr11, 69.92 cM, cytoband F3-G1
• Alliance: Pecam1^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53225
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 7 of the gene. No functional protein was expressed on the surface of PBLs as demonstrated by flow cytometry analysis. (J:53225)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pecam1 Mutation: 227 strains or lines available

References

• Original: J:53225 Duncan GS, et al., Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol. 1999 Mar 1;162(5):3022-30
• All: 74 reference(s)