Sall1^tm1Mrau
Targeted Allele Detail

Summary

• Symbol: Sall1^tm1Mrau
• Name: spalt like transcription factor 1; targeted mutation 1, Michael Rauchman
• MGI ID: MGI:2677452
• Synonyms: sall1^delta, Sall1-deltaZn, Sall1-deltaZn^2-10
• Gene: Sall1 Location: Chr8:89753867-89770790 bp, - strand Genetic Position: Chr8, 43.51 cM, cytoband D
• Alliance: Sall1^tm1Mrau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85458
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Dominant negative)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A dominant-negative allele, recapitulating the human SALL1 1277-1278delGA mutation, was generated by inserting a stop codon and a floxed neo cassette into the exon 2. The deleted region corresponded with nt 1300-3443 of the cDNA. A truncated protein was detected by Western blot analyis of homozygous mutant embryonic tissue using an N-terminal antibody. (J:85458)

Disease models

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sall1 Mutation: 78 strains or lines available

References

• Original: J:85458 Kiefer SM, et al., Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects. Hum Mol Genet. 2003 Sep 1;12(17):2221-7
• All: 5 reference(s)