Grb2tm2Paw
Targeted Allele Detail
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Symbol: |
Grb2tm2Paw |
Name: |
growth factor receptor bound protein 2; targeted mutation 2, Tony Pawson |
MGI ID: |
MGI:2677457 |
Synonyms: |
E89K |
Gene: |
Grb2 Location: Chr11:115534871-115599423 bp, - strand Genetic Position: Chr11, 80.91 cM
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Alliance: |
Grb2tm2Paw page
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Germline Transmission: |
Earliest citation of germline transmission:
J:69138
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Hypomorph) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: A G-to-A mutation was introduced into codon 89 to alter this residue in the corresponding protein from a glutamate to a lysine through homologous recombination. A loxP-flanked neomycin selection cassette also introduced into intron 2 was deleted by cre-mediated recombination, resulting in a single loxP site remaining in the intron. This allele expresses a mutant protein and is thought to be hypomorphic.
(J:69138)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Grb2 Mutation: |
43 strains or lines available
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Original: |
J:69138 Saxton TM, et al., Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Curr Biol. 2001 May 1;11(9):662-70 |
All: |
2 reference(s) |
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