Pdpk1^tm1Mlw
Targeted Allele Detail

Summary

• Symbol: Pdpk1^tm1Mlw
• Name: 3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Margaret A Lawlor
• MGI ID: MGI:2677460
• Synonyms: PDK1^FL, pdk1^hm, PDK^fl, pdk^hm
• Gene: Pdpk1 Location: Chr17:24292654-24369898 bp, - strand Genetic Position: Chr17, 12.23 cM, cytoband A3.3
• Alliance: Pdpk1^tm1Mlw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85894
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin cassette was inserted in intron 2 while an additional loxP site was inserted in intron 4. Presence of the neomycin gene in intron 2 results in reduced PDK1 levels. (J:85894)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pdpk1^tm1Mlw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpk1 Mutation: 138 strains or lines available

References

• Original: J:85894 Lawlor MA, et al., Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 2002 Jul 15;21(14):3728-38
• All: 19 reference(s)