Pdpk1^tm1.1Mlw
Targeted Allele Detail

Summary

• Symbol: Pdpk1^tm1.1Mlw
• Name: 3-phosphoinositide dependent protein kinase 1; targeted mutation 1.1, Margaret A Lawlor
• MGI ID: MGI:2677461
• Synonyms: Pdk1^L, PDK-1^lox, PDK^{fl delta neo}
• Gene: Pdpk1 Location: Chr17:24292654-24369898 bp, - strand Genetic Position: Chr17, 12.23 cM, cytoband A3.3
• Alliance: Pdpk1^tm1.1Mlw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85894
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele is derived from Pdpk1^tm1Mlw by cre mediated excision of neomycin. The resulting gene has loxP sites flanking exons 3 and 4. Removal of the neomycin gene restores PDK1 activity. (J:85894)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pdpk1^tm1.1Mlw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpk1 Mutation: 138 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Inflammatory Skin Disease J:226194

References

• Original: J:85894 Lawlor MA, et al., Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 2002 Jul 15;21(14):3728-38
• All: 44 reference(s)