Lipe^tm1Land
Targeted Allele Detail

Summary

• Symbol: Lipe^tm1Land
• Name: lipase, hormone sensitive; targeted mutation 1, Dominique Langin
• MGI ID: MGI:2677463
• Synonyms: HSL
• Gene: Lipe Location: Chr7:25078952-25097911 bp, - strand Genetic Position: Chr7, 13.78 cM, cytoband A3
• Alliance: Lipe^tm1Land page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85895
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The catalytic domain was disrupted by the insertion of GFP and neo into exon 5. Protein was undetected in homozygous mutant mice by Western blot analysis of intestinal mucosa extracts. Cholesterol esterase activity was completely abolished in the intestinal mucosa of homozygous mutant mice. (J:85895)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lipe Mutation: 37 strains or lines available

References

• Original: J:85895 Grober J, et al., Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa. J Biol Chem. 2003 Feb 21;278(8):6510-5
• All: 17 reference(s)