Ern2^tm1Dron
Targeted Allele Detail

Summary

• Symbol: Ern2^tm1Dron
• Name: endoplasmic reticulum to nucleus signalling 2; targeted mutation 1, David Ron
• MGI ID: MGI:2677494
• Synonyms: IRE1beta -
• Gene: Ern2 Location: Chr7:121769116-121785430 bp, - strand Genetic Position: Chr7, 65.53 cM
• Alliance: Ern2^tm1Dron page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67934
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced 2.6 kb of genomic DNA that contains exons 12 and 13 which encode amino acid residues 408-497 in the transmembrane domain. Immunoprecipitation and western blot analysis demonstrated that no detectable protein is produced from this allele in colonic mucosa. (J:67934)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ern2 Mutation: 42 strains or lines available

References

• Original: J:67934 Bertolotti A, et al., Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest. 2001 Mar;107(5):585-93
• All: 7 reference(s)