Hba-x^tm1Led
Targeted Allele Detail

Summary

• Symbol: Hba-x^tm1Led
• Name: hemoglobin X, alpha-like embryonic chain in Hba complex; targeted mutation 1, Philip Leder
• MGI ID: MGI:2677497
• Synonyms: zeta-, zeta-null
• Gene: Hba-x Location: Chr11:32226600-32228116 bp, + strand Genetic Position: Chr11, 18.86 cM
• Alliance: Hba-x^tm1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41934
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the first exon of the gene. Northern blot analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript is expressed from this allele. (J:41934)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hba-x Mutation: 10 strains or lines available

References

• Original: J:41934 Leder A, et al., Mouse zeta- and alpha-globin genes: Embryonic survival, alpha-thalassemia, and genetic background effects. Blood. 1997 AUG 1;90(3):1275-1282
• All: 2 reference(s)