Pde6g^tm1Goff
Targeted Allele Detail

Summary

• Symbol: Pde6g^tm1Goff
• Name: phosphodiesterase 6G, cGMP-specific, rod, gamma; targeted mutation 1, Stephen P Goff
• MGI ID: MGI:2677504
• Synonyms: Pdeg^tm1
• Gene: Pde6g Location: Chr11:120338433-120344326 bp, - strand Genetic Position: Chr11, 84.14 cM
• Alliance: Pde6g^tm1Goff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33048
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced genomic sequences including the third exon. Western blot analysis on retinal homogenates derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:33048)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde6g Mutation: 11 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or CCE (129S/SvEv-Gpi1^c). Animals derived from either line were not distinguished in J:33048.

References

• Original: J:33048 Tsang SH, et al., Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase. Science. 1996 May 17;272(5264):1026-9
• All: 13 reference(s)