Vhl^tm1Lss
Targeted Allele Detail

Summary

• Symbol: Vhl^tm1Lss
• Name: von Hippel-Lindau tumor suppressor; targeted mutation 1, Laura S Schmidt
• MGI ID: MGI:2677574
• Synonyms: VHL^f
• Gene: Vhl Location: Chr6:113600955-113608595 bp, + strand Genetic Position: Chr6, 52.81 cM
• Alliance: Vhl^tm1Lss page

Vhl^tm1Lss/Vhl^tm1Lss Tg(Pdx1-cre)89.1Dam/0 mice develop microcystic adenomas in the pancreas

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85513
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 2 and 3 were flanked by single loxP sites. (J:85513)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Vhl^tm1Lss

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vhl Mutation: 18 strains or lines available

References

• Original: J:85513 Ma W, et al., Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res. 2003 Sep 1;63(17):5320-8
• All: 7 reference(s)