Hba-a1^tm1Ywk
Targeted Allele Detail

Summary

• Symbol: Hba-a1^tm1Ywk
• Name: hemoglobin alpha, adult chain 1; targeted mutation 1, Yuet Wai Kan
• MGI ID: MGI:2677594
• Synonyms: *alpha
• Gene: Hba-a1 Location: Chr11:32233672-32234486 bp, + strand Genetic Position: Chr11, 18.86 cM
• Alliance: Hba-a1^tm1Ywk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35018
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette replaced part of the second exon of the gene. (J:35018)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hba-a1 Mutation: 3 strains or lines available

References

• Original: J:35018 Chang J, et al., Inactivation of mouse alpha-globin gene by homologous recombination: mouse model of hemoglobin H disease. Blood. 1996 Sep 1;88(5):1846-51
• All: 5 reference(s)