Cntn2^tm1Furl
Targeted Allele Detail

Summary

• Symbol: Cntn2^tm1Furl
• Name: contactin 2; targeted mutation 1, Andrew Furley
• MGI ID: MGI:2677610
• Synonyms: Cntn2^tm1Pele, TAG-1-, TAG1-tau-lacZ
• Gene: Cntn2 Location: Chr1:132437163-132470989 bp, - strand Genetic Position: Chr1, 57.42 cM
• Alliance: Cntn2^tm1Furl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85502
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced with a cassette containing tau-lacZ and neo. The deleted region included the start codon, and sequence encoding the signal peptide and first two Ig domains. Neither transcript nor protein was detected by RT-PCR and Western blot analysis of homozygous mutant mice. Immunolabeling of sciatic nerve tissue showed no specific staining. (J:85502)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cntn2 Mutation: 56 strains or lines available

References

• Original: J:85502 Poliak S, et al., Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol. 2003 Sep 15;162(6):1149-60
• All: 10 reference(s)