Cntnap2^tm1Pele
Targeted Allele Detail

Summary

• Symbol: Cntnap2^tm1Pele
• Name: contactin associated protein-like 2; targeted mutation 1, Elior Peles
• MGI ID: MGI:2677631
• Synonyms: Caspr2-
• Gene: Cntnap2 Location: Chr6:45036995-47278330 bp, + strand Genetic Position: Chr6, 21.81 cM, cytoband B2
• Alliance: Cntnap2^tm1Pele page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85502
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which contains the start codon encodes the signal peptide, was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of homozygous mutant brain RNA. Protein was undetected in the central nervous system of homozygous mutant mice by immunoprecipitation and Western blot analysis. Similarly, no specific staining was observed by immunolabeling of sciatic nerve tissue. (J:85502)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cntnap2 Mutation: 94 strains or lines available

References

• Original: J:85502 Poliak S, et al., Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol. 2003 Sep 15;162(6):1149-60
• All: 86 reference(s)