Tg(ACTB-cre)1Tes
Transgene Detail

Summary

• Symbol: Tg(ACTB-cre)1Tes
• Name: transgene insertion 1, Lino Tessarollo
• MGI ID: MGI:2677702
• Transgene: Tg(ACTB-cre)1Tes Location: unknown
• Alliance: Tg(ACTB-cre)1Tes page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(ACTB-cre)1Tes expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTB (60)

  Actb	(MGI:87904)

• Mutation details: The sequence encoding cre recombinase was under the control of the human beta-actin promoter. This line differs from other beta-actin driven transgenes in that expression was driven during early embryogenesis in a stochastic manner. While uniform transgenic expression was detected in the testis, mosaic patterns of cre-mediated recombination were observed in various organs including the liver, heart, lung, pancreas, brain, retina, spleen, and adrenal gland. (J:85513)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	ACTB (human) Summary of all recombinase alleles driven by ACTB. Comparative matrix view of recombinase activities Alliance human ACTB gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(ACTB-cre)1Tes

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:85513 Ma W, et al., Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res. 2003 Sep 1;63(17):5320-8
• All: 5 reference(s)