Tg(CAG-cre/Esr1*)1Lbe
Transgene Detail
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Symbol: |
Tg(CAG-cre/Esr1*)1Lbe |
Name: |
transgene insertion 1, Corrinne Lobe |
MGI ID: |
MGI:2677720 |
Synonyms: |
actin-creER, beta-actin-CreER, CAGG-CreER, CX-CreERx, pCX-CreERTM, Tg(ACTB-cre/Esr1)1Lbe, Tg(CAG-cre/Esr1)1Lbe |
Transgene: |
Tg(CAG-cre/Esr1*)1Lbe Location: unknown
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Alliance: |
Tg(CAG-cre/Esr1*)1Lbe page
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Transgene Type: |
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Transgenic (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Tg(CAG-cre/Esr1*)1Lbe expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
chicken |
CAG |
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Mutation details: This transgenic construct was generated by ligating sequence encoding a fusion protein of cre recombinase and a mutant mouse estrogen receptor ligand binding domain to a CMV early enhancer and chicken beta-actin promoter. In the absence of ligand binding, the fusion protein remains in the cytoplasm. Binding of 4-hydroxytamoxifen enables the fusion protein to move to nucleus where it may act upon DNA. This transgenic line was generated by electroporating the contstruct into ES cells. Expression of the fusion protein was in a widespread mosaic pattern. Two lines were generated, BD8 with two copies of the transgene and CA6 with one copy.
(J:81562)
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Activity: |
![](https://www.informatics.jax.org/webshare/images/rightArrow.gif) Tissue activity of this recombinase allele
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Driver:
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CAG
(chicken)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:81562 Guo C, et al., A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis. 2002 Jan;32(1):8-18 |
All: |
40 reference(s) |
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