Bag4^tm1Kpf
Targeted Allele Detail

Summary

• Symbol: Bag4^tm1Kpf
• Name: BCL2-associated athanogene 4; targeted mutation 1, Klaus Pfeffer
• MGI ID: MGI:2677764
• Synonyms: Sodd^-
• Gene: Bag4 Location: Chr8:26254566-26275237 bp, - strand Genetic Position: Chr8, 14.17 cM, cytoband A3
• Alliance: Bag4^tm1Kpf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85442
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Starting shortly after the start codon, exon 1 was replaced by a neomycin resistance cassette in opposite orientation. Western blot analysis of liver protein extracts confirmed the absence of translation product. (J:85442)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Bag4^tm1Kpf/Bag4^tm1Kpf	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1
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normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bag4 Mutation: 33 strains or lines available

References

• Original: J:85442 Endres R, et al., Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains. Mol Cell Biol. 2003 Sep;23(18):6609-17
• All: 1 reference(s)