Terf1^tm1Tdl
Targeted Allele Detail

Summary

• Symbol: Terf1^tm1Tdl
• Name: telomeric repeat binding factor 1; targeted mutation 1, Titia de Lange
• MGI ID: MGI:2677837
• Synonyms: Terf^ex1delta
• Gene: Terf1 Location: Chr1:15875870-15914276 bp, + strand Genetic Position: Chr1, 4.88 cM, cytoband E3
• Alliance: Terf1^tm1Tdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85440
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a neomycin resistance gene. Northern blot analysis of RNA purified from heterozygotes indicated only about half of the normal amount of mRNA transcript was present. No truncated mRNA species were observed. (J:85440)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Terf1 Mutation: 37 strains or lines available

References

• Original: J:85440 Karlseder J, et al., Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol. 2003 Sep;23(18):6533-41
• All: 4 reference(s)