Sftpb^tm1Jaw
Targeted Allele Detail

Summary

• Symbol: Sftpb^tm1Jaw
• Name: surfactant associated protein B; targeted mutation 1, Jeffrey A Whitsett
• MGI ID: MGI:2677852
• Synonyms: SP-B-
• Gene: Sftpb Location: Chr6:72281594-72291354 bp, + strand Genetic Position: Chr6, 32.27 cM
• Alliance: Sftpb^tm1Jaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28289
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted in the 5' region of the endogenous gene by homologous recombination. Neither transcript nor protein was detected in homozygous mutant mice. (J:28289)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sftpb Mutation: 15 strains or lines available

References

• Original: J:28289 Clark JC, et al., Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7794-8
• All: 16 reference(s)