Myl1^tm1Nros
Targeted Allele Detail

Summary

• Symbol: Myl1^tm1Nros
• Name: myosin, light polypeptide 1; targeted mutation 1, Nadia Rosenthal
• MGI ID: MGI:2677883
• Synonyms: MLCE^-
• Gene: Myl1 Location: Chr1:66963454-66984563 bp, - strand Genetic Position: Chr1, 33.71 cM
• Alliance: Myl1^tm1Nros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77516
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Other
• Mutation details: The MLC downstream enhancer was deleted via two steps of homologous recombination. Ultimately, the allele lacked the MLC downstream enchancer and surrounding sequence (a 1.5 kb genomic fragment) and contained no exogenous sequence. (J:77516)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myl1 Mutation: 17 strains or lines available

References

• Original: J:77516 Jiang P, et al., Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation. Dev Biol. 2002 Mar 15;243(2):281-93
• All: 1 reference(s)