Hif1a^tm1Stom
Targeted Allele Detail

Summary

• Symbol: Hif1a^tm1Stom
• Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Shuhei Tomita
• MGI ID: MGI:2677892
• Synonyms: Hif-1alpha^F, Hif-1alpha^flox
• Gene: Hif1a Location: Chr12:73948186-73994304 bp, + strand Genetic Position: Chr12, 31.99 cM
• Alliance: Hif1a^tm1Stom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 13, 14, and 15 were flanked by single loxP sites. The floxed region encodes the C-terminal transactivation domain that is involved in response to hypoxia, Cri2 recruitment, and efficient nuclear localization. (J:85763)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hif1a^tm1Stom

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hif1a Mutation: 50 strains or lines available

References

• Original: J:85763 Tomita S, et al., Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol. 2003 Oct;23(19):6739-49
• All: 40 reference(s)