Mafb^tm1Mhs
Targeted Allele Detail

Summary

• Symbol: Mafb^tm1Mhs
• Name: MAF bZIP transcription factor B; targeted mutation 1, Michael H Sieweke
• MGI ID: MGI:2677917
• Synonyms: Mafb^-, MafB^GFP
• Gene: Mafb Location: Chr2:160205623-160208985 bp, - strand Genetic Position: Chr2, 80.92 cM
• Alliance: Mafb^tm1Mhs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85746
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a cassette containing GFP and neoR. Protein was undetected by Western blot analysis of macrophages obtained from homozygous mutant mice. (J:85746)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mafb Mutation: 20 strains or lines available

References

• Original: J:85746 Blanchi B, et al., MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth. Nat Neurosci. 2003 Oct;6(10):1091-100
• All: 7 reference(s)