Pura^tm1Kkh
Targeted Allele Detail

Summary

• Symbol: Pura^tm1Kkh
• Name: purine rich element binding protein A; targeted mutation 1, Kamel Khalili
• MGI ID: MGI:2677937
• Synonyms: PURA^-
• Gene: Pura Location: Chr18:36414150-36425588 bp, + strand Genetic Position: Chr18, 19.46 cM, cytoband B3
• Alliance: Pura^tm1Kkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85759
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was disrupted by a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of homozygous mutant brain tissue. (J:85759)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pura Mutation: 26 strains or lines available

References

• Original: J:85759 Khalili K, et al., Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse. Mol Cell Biol. 2003 Oct;23(19):6857-75
• All: 3 reference(s)