Sftpa1^tm2Haw
Targeted Allele Detail

Summary

• Symbol: Sftpa1^tm2Haw
• Name: surfactant associated protein A1; targeted mutation 2, Samuel Hawgood
• MGI ID: MGI:2677968
• Synonyms: SP-AD(-)
• Gene: Sftpa1 Location: Chr14:40853745-40858330 bp, + strand Genetic Position: Chr14, 22.36 cM
• Alliance: Sftpa1^tm2Haw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86022
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2, 3, and 4, including the translation start site and short segments of flanking intronic sequence were replaced with a PGK-neo cassette. Correctly targeted ES cells were subsequently used to target Sftpd thus producing double mutant ES cells. (J:86022)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sftpa1 Mutation: 21 strains or lines available

References

• Original: J:86022 Hawgood S, et al., Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1002-10
• All: 6 reference(s)