Fabp3^tm1Bin
Targeted Allele Detail

Summary

• Symbol: Fabp3^tm1Bin
• Name: fatty acid binding protein 3, muscle and heart; targeted mutation 1, Bert Binas
• MGI ID: MGI:2677970
• Synonyms: H-FABP^-
• Gene: Fabp3 Location: Chr4:130202531-130209256 bp, + strand Genetic Position: Chr4, 63.43 cM
• Alliance: Fabp3^tm1Bin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54614
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence fragment containing the entire coding region was replaced with an PGK-HRPT mini gene inserted by homologous recombination. Neither transcript nor protein was detected through Northern and Western blot analysis of homozygous mutant mice. (J:54614)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fabp3 Mutation: 67 strains or lines available

Notes

Homozygous mice may provide a model for some human cardiomyopathies thought to be caused by depressed myocardial long chain fatty acid utilization (J:54614).

References

• Original: J:54614 Binas B, et al., Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization. FASEB J. 1999 May;13(8):805-12
• All: 19 reference(s)