Apc^tm2Tno
Targeted Allele Detail

Summary

• Symbol: Apc^tm2Tno
• Name: APC, WNT signaling pathway regulator; targeted mutation 2, Tetsuo Noda
• MGI ID: MGI:2678005
• Synonyms: Apc¹³⁰⁹, APC 1309, APC1309, Apcdelta1309
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm2Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47857
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A frameshift mutation was introduced at codon 1309 via homolgous recombination, a most common germline mutation for human families susceptible to familial adenomatous polyposis coli (FAP). (J:47857)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm2Tno

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:47857 Quesada CF, et al., Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal adenomas in APC gene 1309 knockout mice. Jpn J Cancer Res. 1998 Apr;89(4):392-6
• All: 7 reference(s)