Tmevd5¹²⁹
QTL Variant Detail

Summary

• QTL variant: Tmevd5¹²⁹
• Name: Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5; 129
• MGI ID: MGI:2678009
• QTL: Tmevd5 Location: Chr11:89726125-89726289 bp Genetic Position: Chr11, cM position of peak correlated region/allele: 54.6 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: 129-Ifngr1^tm1Agt/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased demyelinating disease severity compared to C57BL/6J.
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:69154

Two F2 intercrosses [(C57BL/6J Ifng-/- x 129/Sv)F2 and (C57BL/6J x 129/Sv Ifngr-/-)F2] were used to map a locus, Tmevd5 (LOD = 4.8 with D11Mit179), on mouse Chromosome 11 (33.4 cM - 47.7 cM) influencing the severity of demyelinating disease caused by Theiler's virus. C57BL/6J Ifng-/- is less susceptible to viral infection and disease-related symptoms than 129/Sv Ifngr-/-. 45 days post-inoculation with Theiler's virus, animals from both F2 crosses showed a higher viral load than animals from either parental strain (C57BL/6J Ifng-/- or 129/Sv Ifngr-/-). Tmevd5 was identified in the (C57BL/6J x 129/Sv Ifngr-/-)F2 cross using both male and female mice. Further analysis revealed a suggestive locus influencing disease severity in female mice on Chromosome 19 linked to D19Mit65 (LOD = 2.9), D19Mit119 (LOD = 2.9), and D19Mit83 (LOD = 2.6).

References

• Original: J:69154 Aubagnac S, et al., Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus. J Virol. 1999 Oct;73(10):7965-71
• All: 1 reference(s)