Pawr^tm1Jmos
Targeted Allele Detail

Summary

• Symbol: Pawr^tm1Jmos
• Name: PRKC, apoptosis, WT1, regulator; targeted mutation 1, Jorge Moscat
• MGI ID: MGI:2678021
• Synonyms: Par4^-
• Gene: Pawr Location: Chr10:108167982-108250101 bp, + strand Genetic Position: Chr10, 56.43 cM, cytoband D1
• Alliance: Pawr^tm1Jmos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86034
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin resistance gene. Embryonic fibroblasts derived from mice homozygous for this allele did not express the protein. (J:86034)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pawr^tm1Jmos

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pawr Mutation: 20 strains or lines available

References

• Original: J:86034 Garcia-Cao I, et al., Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38. EMBO Rep. 2003 Mar;4(3):307-12
• All: 8 reference(s)