Unc5c^{rcmTg(Tert)5Hwl}
Transgenic Allele Detail

Summary

• Symbol: Unc5c^{rcmTg(Tert)5Hwl}
• Name: unc-5 netrin receptor C; transgene insertion 5, Han-Woong Lee
• MGI ID: MGI:2678074
• Synonyms: Unc5c^{rcmTgN(Tert)5Hwl}
• Gene: Unc5c Location: Chr3:141171360-141540685 bp, + strand Genetic Position: Chr3, 65.57 cM
• Alliance: Unc5c^{rcmTg(Tert)5Hwl} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: A 5.6 kb transgenic construct containing cDNA encoding telomerase reverse transcriptase under the control of the chicken beta-actin promoter randomly inserted into intron 1 of Unc5c. The insertion deleted approximately 50 kb of intron 1. While Unc5c transcript was detected in the testes of homozygous mutant mice, transcript was undetected in the cerebellum, lung, spleen, or ovaries. (J:85446)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc5c Mutation: 61 strains or lines available

References

• Original: J:85446 Choi YS, et al., Insertional mutation in the intron 1 of Unc5h3 gene induces ataxic, lean and hyperactive phenotype in mice. Exp Anim. 2003 Jul;52(4):273-83
• All: 1 reference(s)