Crhr1^tm2Wrst
Targeted Allele Detail

Summary

• Symbol: Crhr1^tm2Wrst
• Name: corticotropin releasing hormone receptor 1; targeted mutation 2, Wolfgang Wurst
• MGI ID: MGI:2678096
• Synonyms: CRF-R1^loxP, Crhr1^lox
• Gene: Crhr1 Location: Chr11:104023681-104066349 bp, + strand Genetic Position: Chr11, 67.77 cM
• Alliance: Crhr1^tm2Wrst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85745
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 9 through 13 were flanked by a 5' single loxP site and 3' single loxP site followed by a splice acceptor, lacZ, and neo. The floxed sequence encodes transmembrane regions 4 through 7, the G-protein coupling domain, and the intracellular cytoplasmic tail. (J:85745)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crhr1 Mutation: 28 strains or lines available

References

• Original: J:85745 Muller MB, et al., Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci. 2003 Oct;6(10):1100-7
• All: 17 reference(s)