Cops3^tm1Jrl
Targeted Allele Detail

Summary

• Symbol: Cops3^tm1Jrl
• Name: COP9 signalosome subunit 3; targeted mutation 1, James R Lupski
• MGI ID: MGI:2678261
• Synonyms: Csn3-, Csn3^5'm
• Gene: Cops3 Location: Chr11:59708621-59730664 bp, - strand Genetic Position: Chr11, 37.8 cM, cytoband B2
• Alliance: Cops3^tm1Jrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85760
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A 5'HPRT minigene segment along with a neomycin resistance gene was inserted after exon 6 and was followed by a duplication of exons 3-6 with about 10kb of vector sequence. No protein product could be identified in homozygotes by western blot analysis. (J:85760)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cops3 Mutation: 26 strains or lines available

References

• Original: J:85760 Yan J, et al., COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol. 2003 Oct;23(19):6798-808
• All: 1 reference(s)