Cops2^tm1Nwe
Targeted Allele Detail

Summary

• Symbol: Cops2^tm1Nwe
• Name: COP9 signalosome subunit 2; targeted mutation 1, Ning Wei
• MGI ID: MGI:2678281
• Synonyms: Csn2^-
• Gene: Cops2 Location: Chr2:125672222-125701002 bp, - strand Genetic Position: Chr2, 61.76 cM
• Alliance: Cops2^tm1Nwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Exons 3 and 4 were replaced with a lacZ-neo cassette which disrupted the gene. (J:85761)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cops2 Mutation: 18 strains or lines available

References

• Original: J:85761 Lykke-Andersen K, et al., Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol. 2003 Oct;23(19):6790-7
• All: 1 reference(s)