Bdnf^tm1Sieg
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Sieg
• Name: brain derived neurotrophic factor; targeted mutation 1, Steven A Siegelbaum
• MGI ID: MGI:2678286
• Synonyms: BDNF^f, BDNF^flox
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Sieg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85602
• Parent Cell Line: MM13 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 5 was flanked by single loxP sites. Gene expression was reported to be unaffected by the loxP sites. (J:85602)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:85602 Zakharenko SS, et al., Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron. 2003 Sep 11;39(6):975-90
• All: 7 reference(s)