Mnt^tm1.1Phu
Targeted Allele Detail

Summary

• Symbol: Mnt^tm1.1Phu
• Name: max binding protein; targeted mutation 1.1, Peter J Hurlin
• MGI ID: MGI:2678322
• Synonyms: Mnt^-
• Gene: Mnt Location: Chr11:74721746-74736551 bp, + strand Genetic Position: Chr11, 45.76 cM, cytoband B-C
• Alliance: Mnt^tm1.1Phu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85481
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice heterozygous for Mnt^tm1Phu were crossed with transgenic mice carryingTgN(EIIa-cre)C5379Lmgd. In mice carrying both the transgene and Mnt^tm1Phu, cre excision removed exons 4 to 6 as well as the Hygro selection cassette. The predicted protein product would thus lack the C-terminal amino acids from residue 235 to 591. No mRNA transcripts were identified by RT-PCR in embryos homozygous for this disruption. (J:85481)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mnt Mutation: 26 strains or lines available

References

• Original: J:85481 Hurlin PJ, et al., Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 2003 Sep 15;22(18):4584-96
• All: 2 reference(s)