Ntrk1^tm1Apat
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm1Apat
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Ardem Patapoutian
• MGI ID: MGI:2678328
• Synonyms: Ntrk1^-, TkrA^taulacZ, TrkA^LacZ, TrkA(tauLacZ)*tm1Lfr
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm1Apat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92099
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector containing tau-lacZ, SV40 polyA and floxed neo was inserted immediately downstream of the ATG in exon 1. Crossing with Actb-cre mice excised the floxed neo. Southern blot confirmed recombination. X-gal staining indicated expression of lacZ in dorsal root ganglia and skin in heterozygotes. (J:92099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 62 strains or lines available

References

• Original: J:92099 Moqrich A, et al., Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci. 2004 Aug;7(8):812-8
• All: 7 reference(s)