Gucy2c^tm1Gian
Targeted Allele Detail

Summary

• Symbol: Gucy2c^tm1Gian
• Name: guanylate cyclase 2c; targeted mutation 1, Ralph A Giannella
• MGI ID: MGI:2678361
• Synonyms: GC-C-, GCC-
• Gene: Gucy2c Location: Chr6:136674282-136758740 bp, - strand Genetic Position: Chr6, 66.67 cM
• Alliance: Gucy2c^tm1Gian page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43682
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with an hprt cassette inserted by homologous recombination. Transcript was undetected in the jejunum and ileum of homozygous mutant mice by Northern blot analysis. Western blot analysis using an antibody against the extracellular domain indicated the absence of protein in the jejunum. (J:43682)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gucy2c Mutation: 69 strains or lines available

References

• Original: J:43682 Mann EA, et al., Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion. Biochem Biophys Res Commun. 1997 Oct 20;239(2):463-6
• All: 13 reference(s)