Pmaip1^tm1Ttg
Targeted Allele Detail

Summary

• Symbol: Pmaip1^tm1Ttg
• Name: phorbol-12-myristate-13-acetate-induced protein 1; targeted mutation 1, Tadatsugu Taniguchi
• MGI ID: MGI:2678372
• Synonyms: Noxa^-
• Gene: Pmaip1 Location: Chr18:66591675-66598629 bp, + strand Genetic Position: Chr18, 39.52 cM, cytoband E1
• Alliance: Pmaip1^tm1Ttg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85569
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.4 kb genomic freagment encompassing exons 1 and 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analysis of homozygous mutant MEFs treated with adriamycin, which stimulates expression in wild-type MEFs. (J:85569)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pmaip1 Mutation: 12 strains or lines available

References

• Original: J:85569 Shibue T, et al., Integral role of Noxa in p53-mediated apoptotic response. Genes Dev. 2003 Sep 15;17(18):2233-8
• All: 5 reference(s)