Impdh2^tm1Bmi
Targeted Allele Detail

Summary

• Symbol: Impdh2^tm1Bmi
• Name: inosine monophosphate dehydrogenase 2; targeted mutation 1, Beverly S Mitchell
• MGI ID: MGI:2678388
• Synonyms: IMPDH II ^-
• Gene: Impdh2 Location: Chr9:108437635-108442776 bp, + strand Genetic Position: Chr9, 59.5 cM
• Alliance: Impdh2^tm1Bmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86045
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 6-9 were replaced with a PGK-neomycin resistance gene. (J:86045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Impdh2 Mutation: 41 strains or lines available

References

• Original: J:86045 Gu JJ, et al., Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene. J Clin Invest. 2000 Aug;106(4):599-606
• All: 2 reference(s)