Hdlq4^SM/J
QTL Variant Detail

Summary

• QTL variant: Hdlq4^SM/J
• Name: HDL QTL 4; SM/J
• MGI ID: MGI:2678539
• QTL: Hdlq4 Location: unknown Genetic Position: Chr15, cM position of peak correlated region/allele: 52.36 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Heterozygous animals exhibit increased induction of HDL cholesterol concentrations on a high fat diet. (J:76707)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76707

90 female animals from an (SM/J x NZB/BlNJ)F1 x NZB/BlNJ backcross population were screened for an initial set of 78 SSLP markers to identify QTLs associated with HDL cholesterol (HDL-C) concentrations. Parental strain NZB/BlNJ exhibits elevated HDL-C onboth a CHOW and atherogenic diet compared to parental SM/J and F1 hybrid animals. A QTL linked to inducible HDL-C on an atherogenic diet, Hdlq4, mapped to 56 cM on mouse Chromosome 15 near D15Mit39 (LOD=2.5). Heterozygous animals exhibit increased induction of HDL cholesterol concentrations at Hdlq4. A possible candidage gene for this locus is Ppara. Suggestive loci were also detected near D6Mit44 (48 cM) and D18Mit24 (18 cM) in linkage to inducible HDL-C, and on mouse Chromosome 11 at 14 cM and 44 cM inlinkage to non-HDL-C on a CHOW diet and non-HDL-C on an atherogenic diet, respectively.

References

• Original: J:76707 Pitman WA, et al., Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics. 2002;9(2):93-102
• All: 1 reference(s)