Ifnb1^tm1Ttg
Targeted Allele Detail

Summary

• Symbol: Ifnb1^tm1Ttg
• Name: interferon beta 1, fibroblast; targeted mutation 1, Tadatsugu Taniguchi
• MGI ID: MGI:2678753
• Synonyms: Ifnb1^tm1Ttg, IFN-Beta^-, Ifnb^tm1(lacZ)
• Gene: Ifnb1 Location: Chr4:88440262-88441011 bp, - strand Genetic Position: Chr4, 41.91 cM
• Alliance: Ifnb1^tm1Ttg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85824
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted via homologous recombination of a targeting vector that contained a lacZ gene followed by a floxed neo gene. The neo gene was excised via cre-mediated recombination prior to germline transmission. Transcript was undetected by RT-PCR analysis of homozygous mutant MEFs. (J:85824)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifnb1 Mutation: 21 strains or lines available

References

• Original: J:85824 Takaoka A, et al., Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains. Science. 2000 Jun 30;288(5475):2357-60
• All: 9 reference(s)