Traf6^tm1Ywc
Targeted Allele Detail

Summary

• Symbol: Traf6^tm1Ywc
• Name: TNF receptor-associated factor 6; targeted mutation 1, Yongwon Choi
• MGI ID: MGI:2678775
• Synonyms: TRAF6^-, Traf6-deltaT
• Gene: Traf6 Location: Chr2:101508774-101532014 bp, + strand Genetic Position: Chr2, 53.9 cM
• Alliance: Traf6^tm1Ywc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85808
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 7, which encodes the last zinc finger domain and the entire TRAF domain, was deleted via cre-mediated recombination prior to germline transmission. (J:85808)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf6 Mutation: 34 strains or lines available

References

• Original: J:85808 Kobayashi T, et al., TRAF6 is a critical factor for dendritic cell maturation and development. Immunity. 2003 Sep;19(3):353-63
• All: 7 reference(s)