Ikbkb^tm1.1Cgn
Targeted Allele Detail

Summary

• Symbol: Ikbkb^tm1.1Cgn
• Name: inhibitor of kappaB kinase beta; targeted mutation 1.1, University of Cologne
• MGI ID: MGI:2678816
• Synonyms: IkkDeltaK^D
• Gene: Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
• Alliance: Ikbkb^tm1.1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79132
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP flanked region including exon 7 was excised from Ikbkb^tm1Cgn via cre mediated recombination. The deleted region encoded amino acids 160 through 189, including serines 177 and 181, two residues of the activation loop that are essential for kinase activity. Excision of the floxed fragment results in splicing between exons 6 and 8, producing a protein that lacks kinase activity but that is incorporated into the Ikbk complex. (J:85810)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkb Mutation: 56 strains or lines available

References

• Original: J:79132 Pasparakis M, et al., IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med. 2002 Sep 16;196(6):743-52
• All: 3 reference(s)