Thra^tm1Brnt
Targeted Allele Detail

Summary

• Symbol: Thra^tm1Brnt
• Name: thyroid hormone receptor alpha; targeted mutation 1, Gregory A Brent
• MGI ID: MGI:2679056
• Synonyms: P398H, TRalpha P398H
• Gene: Thra Location: Chr11:98631539-98659832 bp, + strand Genetic Position: Chr11, 62.58 cM, cytoband D-E
• Alliance: Thra^tm1Brnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85803
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Dominant negative)
• Mutation: Single point mutation
• Mutation details: A cytosine to adnenosine transversion point mutation was engineered in exon 9, using a "hit and run" strategey, affecting a proline to histidine missense mutation at codon 398 (P398H). The mutation is dominant-negative. (J:86164)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thra Mutation: 40 strains or lines available

References

• Original: J:85803 Liu YY, et al., A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem. 2003 Oct 3;278(40):38913-20
• All: 3 reference(s)