Krt71^rco3
Chemically induced Allele Detail

Summary

• Symbol: Krt71^rco3
• Name: keratin 71; reduced coat 3
• MGI ID: MGI:2679210
• Synonyms: Rco3
• Gene: Krt71 Location: Chr15:101642384-101651532 bp, - strand Genetic Position: Chr15, 57.0 cM
• Alliance: Krt71^rco3 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Intragenic deletion
• Mutation details: This allele is a 10 base pair deletion occuring after the coding sequence for amino acid residue 58. This causes a frameshift such that the remaining protein sequence (residues 59-134) are unlike any known or predicted protein sequence. There is, as well, a total lack of the normal 310 amino acid helical rod domain. (J:85980)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt71 Mutation: 43 strains or lines available

References

• Original: J:85980 Peters T, et al., Alopecia in a novel mouse model RCO3 is caused by mK6irs1 deficiency. J Invest Dermatol. 2003 Oct;121(4):674-80
• All: 1 reference(s)