Fcgr1^tm1Hoga
Targeted Allele Detail

Summary

• Symbol: Fcgr1^tm1Hoga
• Name: Fc receptor, IgG, high affinity I; targeted mutation 1, P Mark Hogarth
• MGI ID: MGI:2679238
• Synonyms: FcgammaRI-, FcRI^-
• Gene: Fcgr1 Location: Chr3:96190225-96201285 bp, - strand Genetic Position: Chr3, 41.72 cM
• Alliance: Fcgr1^tm1Hoga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86280
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 400 bp fragment was deleted from the 5' portion of the gene. This deleted sequence included the promoter and the transcription and translation start sites. In addition a neo cassette was inserted into the second leader exon, disrupting the leader sequence and generating a premature stop codon immediately downstream of exon 2. Transcript was undetected by Northern blot analysis of homozygous bone marrow macrophages (BMM) even after stimulation with interferon gamma. Surface protein was undetected via ligand or antibody binding. (J:86281)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr1 Mutation: 35 strains or lines available

References

• Original: J:86280 Gavin AL, et al., Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity. J Immunol. 1998 Jan 1;160(1):20-3
• All: 36 reference(s)