Kcnip3^tm1Bux
Targeted Allele Detail

Summary

• Symbol: Kcnip3^tm1Bux
• Name: Kv channel interacting protein 3, calsenilin; targeted mutation 1, Joseph D Buxbaum
• MGI ID: MGI:2679303
• Synonyms: dream^-
• Gene: Kcnip3 Location: Chr2:127298418-127364014 bp, - strand Genetic Position: Chr2, 62.02 cM
• Alliance: Kcnip3^tm1Bux page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85927
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a cassette containing IRES-BetaGal followed by MC1-neo. Normal transcript was undetected by Northern blot analysis of RNA obtained from the brains of homozygous mutant mice. Western blot analysis indicated an absence of normal protein in homozygous mutant mice. Beta-galactosidase activity was observed in homozygous mutant mice. (J:85927)

Expression

In Mice Carrying this Mutation:

58 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnip3 Mutation: 26 strains or lines available

References

• Original: J:85927 Lilliehook C, et al., Altered Abeta formation and long-term potentiation in a calsenilin knock-out. J Neurosci. 2003 Oct 8;23(27):9097-106
• All: 2 reference(s)