Prkca^tm1Far
Targeted Allele Detail

Summary

• Symbol: Prkca^tm1Far
• Name: protein kinase C, alpha; targeted mutation 1, Bob Farese
• MGI ID: MGI:2679305
• Synonyms: PKCalpha^-
• Gene: Prkca Location: Chr11:107824213-108234754 bp, - strand Genetic Position: Chr11, 70.8 cM
• Alliance: Prkca^tm1Far page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85923
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin selection cassette via homolgous recombination. Normal transcript was undetected by RT-PCR analysis RNA obtained from the brain tissue of homozygous mutant mice. (J:85923)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Prkca^tm1Far

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkca Mutation: 44 strains or lines available

References

• Original: J:85923 Leitges M, et al., Knockout of PKC alpha enhances insulin signaling through PI3K. Mol Endocrinol. 2002 Apr;16(4):847-58
• All: 40 reference(s)