Ptprq^tm2Bow
Targeted Allele Detail

Summary

• Symbol: Ptprq^tm2Bow
• Name: protein tyrosine phosphatase receptor type Q; targeted mutation 2, Daniel F Bowen-Pope
• MGI ID: MGI:2679316
• Synonyms: Ptprq-CAT-KO
• Gene: Ptprq Location: Chr10:107352910-107555912 bp, - strand Genetic Position: Chr10, 55.97 cM
• Alliance: Ptprq^tm2Bow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85926
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1061 bp fragment encompassing 2 exons, encoding a portion of the cytoplasmic domain including the catalytic site, was replaced with a neomycin selection cassette inserted by homologous recombination. While, mutant transcript lacking the targeted fragment was detected by RT-PCR analysis of cochlear RNA obtained from homozygous mutant mice, protein was undetected by immunostaining. Absence of protein was further verified using antisera to the C-terminal. (J:85926)

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprq Mutation: 134 strains or lines available

References

• Original: J:85926 Goodyear RJ, et al., A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. J Neurosci. 2003 Oct 8;23(27):9208-19
• All: 4 reference(s)